How to Use INBRIJA^®

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INBRIJA logo visible

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Read and follow the accompanying Instructions For Use before you start using INBRIJA^® and each time you get a refill as there may be new information. Remember, the Instructions For Use and this video don’t take the place of talking to your healthcare provider about your medical condition or treatment.

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[Peter waves and holds up inhaler]

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Hi, I’m Peter, and I’m here to show you how to use INBRIJA.

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[Peter turns to talk to another camera while still holding up inhaler]

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Please know that using INBRIJA may take some practice at first.

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[Inhaler sections are laid out on a table and labels animate in]

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Here are the parts to your INBRIJA inhaler.

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[Peter talks to the camera and points his hand]

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Before we continue, here’s some important information to keep in mind.

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[Peter talks to camera and holds up his hand]

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Never swallow INBRIJA capsules.

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Important Information about using INBRIJA Don’t swallow INBRIJA^® capsules

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[Peter holds up inhaler with one hand and motions to it with the other]

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INBRIJA capsules should only be used with the INBRIJA inhaler and inhaled through your mouth.

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Important Information about using INBRIJA INBRIJA capsules should only be used with the INBRIJA^® inhaler and inhaled through your mouth

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[Peter talks to the camera]

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Let’s get started!

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[Peter motions with two fingers]

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Let’s prepare your dose.

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[Peter shows both sides of hands, then holds up inhaler and a strip of capsules]

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Find a clean, dry surface and make sure your hands are clean and dry, too. Then, get your INBRIJA inhaler and a strip of capsules.

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[Peter tears off a package of two capsules]

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Tear off a package of two capsules.

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[Peter holds the capsule package up to the camera]

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Always check the expiration date.

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[Peter pulls off cap of inhaler]

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Then remove the blue cap on the inhaler by pulling it straight off.

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[Peter twists and pulls mouthpiece off]

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Twist and pull off the mouthpiece to separate it from the handle.

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[Peter pulls back foil and removes a capsule]

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Carefully peel back the foil…

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[Peter holds capsule up to the camera]

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…and take out 1 capsule. Remove only 1 capsule at a time, and do that just before you’re ready to use it. Never use any capsule that looks crushed, damaged, or wet. If it does, throw it away and get a new one.

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[Peter holds the inhaler upright]

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Load the capsule by holding the inhaler upright using the handle.

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[Peter drops capsule into the inhaler]

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Drop 1 capsule into the opening of the capsule chamber.

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[Peter holds up two fingers]

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Do not try to load 2 capsules at the same time.

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[Peter lines up the arrows and reattaches the mouthpiece]

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Reattach the white mouthpiece by lining up the white arrows on the handle and mouthpiece.

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[Peter pushes mouthpiece firmly into the handle until it clicks]

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Firmly push the mouthpiece and handle together until you hear a click.

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[Peter talks to the camera and motions with his hands]

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Only do this once because this punctures the capsule. If you push the handle and mouthpiece together more than once, you could damage the capsule, and you may not get your full dose.

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[Peter turns to face another camera and motions with his hands]

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If you push down more than once, throw the capsule in the trash and start over with a new capsule.

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[Peter releases the mouthpiece and holds it up to the camera]

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When you release the mouthpiece, it will spring back and stay attached.

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[Peter holds up inhaler]

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Your inhaler is now ready to use!

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[Peter holds up inhaler level away from his mouth]

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Hold the inhaler level and away from your mouth.

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[Peter holds inhaler up level away from his mouth while standing and looking straight ahead]

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Stand or sit up straight and look straight ahead.

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[Peter breathes out]

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Breathe out.

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[Peter talks to the camera and motions with his hands]

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Do NOT breathe into the mouthpiece.

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[Peter places mouthpiece of inhaler into his mouth]

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While keeping the inhaler level, close your lips firmly around the mouthpiece.

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[Peter takes a breathe from the inhahler]

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Breathe in slowly and gently, just enough to hear or feel the capsule whirl as it spins inside the inhaler.

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[Camera zooms into inhaler in Peter’s mouth]

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The whirl means the inhaler is working and you are getting your medicine.

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[Peter takes inhaler out of his mouth and holds his breath, then breathes out]

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Then, take the inhaler out of your mouth and hold your breath for a few seconds. Then, breathe out.

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[Peter talks to camera and motions with his hands]

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It is quite common to cough when you breathe in, but try not to.

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[Peter turns to talk to another camera and motions with his hands]

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If you cough out the medicine, it will reduce the amount you receive in your body. For some people, coughing may feel like the sensation of choking.

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Just remember, you don’t need to breathe in strongly.

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[Peter removes inhaler from his mouth and then puts it back in]

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You may take more than 1 breath per capsule if it’s easier for you.

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[Peter talks to camera and motions with his hands]

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Some people have found that sipping liquid before and after breathing in the medicine also helps with cough.

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[Peter takes a breath from the inhaler and then removes from mouth]

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Please see the Important Safety Information at the end of this video.

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[Peter points to ear and mouth as he talks to the camera]

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If you didn’t hear or feel the whirl, take deeper, longer breaths until you do.

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If you have any questions, ask your healthcare provider or pharmacist. If you have any problems using INBRIJA, contact INBRIJA support at 1-888- 887-3447.

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[Peter talks to the camera and holds up inhaler]

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If you still don’t hear or feel the whirl, try cleaning the mouthpiece before moving on. We’ll touch more on cleaning the inhaler later.

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[Peter twists and pulls mouthpiece off of handle]

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Twist and pull off the mouthpiece.

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[Peter dumps out used capsule]

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And take out the used capsule.

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[Peter holds up capsule with puncture marks to the camera]

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As you are throwing the capsule away, you will notice that there are 2 puncture marks on the top of it. You may also see powder residue. This is normal.

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[Peter removes second capsule from foil blister package]

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Repeat these steps with the second capsule. Carefully peel back the foil and take it out.

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[Peter drops capsule into the inhaler]

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Load the capsule by holding the inhaler upright using the handle.

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[Peter pushes mouthpiece and handle of inhaler together]

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Line up the white arrows and push the mouthpiece and handle together until you hear a click.

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[Peter holds up inhaler level and looks at it]

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Standing or sitting up straight, hold the inhaler level and away from your mouth.

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[Peter breathes out]

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Breathe out.

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[Peter places mouthpiece in mouth]

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Keeping the inhaler level, close your lips firmly around the mouthpiece.

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[Peter breathes in with inhaler in his mouth]

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And breathe in slowly and gently as you did with the first capsule.

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[Camera zooms into mouthpiece in Peter’s mouth]

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You will hear and feel the capsule whirl.

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[Peter holds his breath and then breathes out]

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Hold your breath for a few seconds. Then, breathe out.

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[Peter removes mouthpiece and dumps out used capsule]

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Twist and pull off the mouthpiece, and remove the used capsule.

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[Peter talks to the camera]

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You’re ready to dispose of the used capsules and store your inhaler.

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[Peter holds capsules in his hand]

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Throw the used...

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[Peter throws capsules into the trash]

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...capsules in the trash.

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[Peter holds up inhaler and motions to it with other hand]

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To avoid powder buildup, you can clean your inhaler as needed.

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[Peter removes mouthpiece]

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Start by removing the white mouthpiece.

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[Peter holds up mouthpiece to camera to show holes on each side of the mouthpiece]

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You will see that there are holes on both sides of the mouthpiece.

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[Peter uses a cotton swab to clean both sides of the mouthpiece]

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Use a new, dry cotton swab to wipe the powder off of the holes from both sides of the mouthpiece using a circular motion.

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[Peter wipes down outside of inhaler with dry tissue]

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You can also use a dry tissue to wipe the outside of the mouthpiece.

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[Peter talks to the camera]

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Do not clean any other parts of the inhaler.

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[Peter holds up inhaler and motions to it with other hand]

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Do not rinse the mouthpiece or get the inhaler wet.

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[Peter talks to the camera]

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Always keep the inhaler and capsules dry.

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[Peter aligns white arrows and replaces mouthpiece and cap]

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Replace the mouthpiece and cap, aligning the white arrows.

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[Peter talks to camera and motions with his hands]

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Never store a capsule inside the inhaler for a future dose.

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[Peter holds up inhaler]

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Always keep the inhaler and capsules dry.

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[Peter holds up empty carton box]

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It’s important to note that once you’ve used all of the capsules in a carton throw out the inhaler.

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[Peter places new carton on table]

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For your next dose, open a new carton. Each one has a new inhaler and capsules.

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[Peter points at camera with inhaler]

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And that’s how to use INBRIJA. Thanks for watching! And please refer back to this video and the Instructions for Use included with each refill any time you need a refresher.

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If you have any problems using INBRIJA, contact INBRIJA support at 1-888-887-3447.

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If you have problems using INBRIJA, contact INBRIJA support at 1-888-887-3447.

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INBRIJA^® (levodopa inhalation powder) is a prescription medicine used when needed for OFF episodes in adults with Parkinson’s treated with regular carbidopa/levodopa medicine. INBRIJA does not replace regular carbidopa/levodopa medicine.

Important Safety Information

Do not use INBRIJA if you take or have taken a nonselective monoamine oxidase inhibitor such as phenelzine or tranylcypromine within the last 2 weeks.

Before using INBRIJA, tell your healthcare provider about your medical conditions, including:

• asthma, chronic obstructive pulmonary disease (COPD), or any chronic lung disease
• daytime sleepiness, sleep disorders, sleepiness/drowsiness without warning, or use of medicine that increases sleepiness, including antidepressants or antipsychotics
• dizziness, nausea, sweating, or fainting when standing up
• abnormal movement (dyskinesia)
• mental health problems such as hallucinations or psychosis
• uncontrollable urges like gambling, sexual urges, spending money, or binge eating
• glaucoma
• pregnancy or plans to become pregnant. It is unknown if INBRIJA will harm an unborn baby.
• breastfeeding or plans to breastfeed. Levodopa can pass into breastmilk and it is unknown if it can harm the baby.

Tell your healthcare provider if you take:

• MAO-B inhibitors
• dopamine (D2) antagonists (including phenothiazines, butyrophenones, risperidone, metoclopramide)
• isoniazid
• iron salts or multivitamins that contain iron salts

Do not drive, operate machinery, or do other activities until you know how INBRIJA affects you. Sleepiness and falling asleep suddenly can happen as late as a year after treatment is started.

Tell your healthcare provider if you experience the following side effects:

• falling asleep during normal daily activities with or without warning. If you become drowsy, do not drive or do activities where you need to be alert. Chances of falling asleep during normal activities increases if you take medicine that cause sleepiness.
• withdrawal-emergent hyperpyrexia and confusion (fever, stiff muscles, or changes in breathing and heartbeat) if you suddenly stop using INBRIJA or carbidopa/levodopa, or suddenly lower your dose of carbidopa/levodopa.
• low blood pressure when standing up (that may be with dizziness, fainting, nausea, and sweating). Get up slowly after sitting/lying down.
• hallucinations and other psychosis – INBRIJA may cause or worsen seeing/hearing/believing things that are not real; confusion, disorientation, or disorganized thinking; trouble sleeping; dreaming a lot; being overly suspicious or feeling people want to harm you; acting aggressive; and feeling agitated/restless.
• unusual uncontrollable urges such as gambling, binge eating, shopping, and sexual urges has occurred in some people using medicine like INBRIJA.
• uncontrolled, sudden body movements (dyskinesia) may be caused or worsened by INBRIJA. INBRIJA may need to be stopped or other Parkinson’s medicines may need to be changed.
• bronchospasm – people with asthma, COPD, or other lung diseases may wheeze or have difficulty breathing after inhaling INBRIJA. If this occurs, stop taking INBRIJA and seek immediate medical attention.
• increased eye pressure in patients with glaucoma. Your healthcare provider should monitor this.
• changes in certain lab values including liver tests

The most common side effects of INBRIJA are cough, upper respiratory tract infection, nausea, and change in the color of saliva or spit.

Do not orally inhale more than 1 dose (2 capsules) for any OFF period. Do not take more than 5 doses (10 capsules) in a day.

Please see accompanying Patient Information Leaflet.

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View the referenced video

02/21 INB9148